SALIVARY DIGOXIN CONCENTRATIONS

Effects of maintenance digoxin therapy on systolic time intervals and serum digoxin concentrations.

or 0.5 mg/day for alternate two-week periods without a loading dose. Control data were obtained both before and after the four weeks of treatment. After 13 days treatment with digoxin, 0.5 mg/day, there was a significant decrease in total electromechanical systole corrected for heart rate (QS2i), pre-ejection period (PEP), pre-ejection period corrected for heart rate (PEP,) and PEP/left ventric...

Falsely raised plasma digoxin concentrations in liver disease.

Plasma and tissue digoxin concentrations in patients undergoing cardiopulmonary bypass.

Plasma myocardial, and skeletal muscle digoxin concentrations were measured in 32 patients undergoing cardiopulmonary bypass who were on long-term treatment with digoxin. The patients were divided into 4 groups according to the daily digoxin dose and the interval between discontinuation of the drug and operation. Before bypass, the mean digoxin concentrations were 1.58 nmol/l (1.24 ng/ml) in pl...

Clinical benefits of low serum digoxin concentrations in heart failure.

OBJECTIVES We sought to determine whether there was a relationship between serum digoxin concentration (SDC), including SDCs typically regarded as low, and clinical efficacy related to digoxin in patients with symptomatic left ventricular dysfunction. BACKGROUND Digitalis glycosides have been used for 200 years in the treatment of heart failure (HF), but the SDC required for optimal clinical ...

Plasma and myocardial digoxin concentrations in patients on oral therapy.

Methods are now available which are sensitive enough to detect digoxin concentration to levels of 5 mug./ml. Hitherto the degree of sensitivity of specific chemical methods was not acceptable for clinical application. Digoxin-specific antibodies have recently been prepared (Butler and Chen, 1967), and a test based on the radioimmunoassay principle has now been used to measure plasma digoxin lev...